Fracture Risk and Risk Factors for Osteoporosis

Environmental risk factors for osteoporosis.

The experiments aimed at evaluating the optimal parameters in the chemo-immunotherapeutic treatment of the L1210 lymphoid leukaemia grafted to [female BALB/c (H2d) x male DBA/2 (H2d)]Fl hybrid mice, hereafter referred to as CDF1 mice. In vitro irradiation of leukaemic ascites cells by X-or y-rays and subsequent inoculation in mice showed that optimum immunogenicity is radiation dose-dependent. ...

Osteoporosis and fracture risk: bone matrix quality.

Male osteoporosis: diagnosis and fracture risk evaluation.

Male osteoporosis is challenging to diagnose and to treat. Underestimation of the risk of male osteoporosis, the combined presence of several interwoven causative factors in many patients, and uncertainty regarding the absorptiometry cutoffs associated with fractures are major obstacles to the diagnosis of male osteoporosis and to the identification of men at risk for fractures. The lifetime ri...

OSTEOPOROSIS and the risk of fracture

Osteoporosis and fracture risk in older people.

Until the 1940s, when Albright associated osteoporosis with a defect of bone anabolism, it was not considered a disease entity but an inevitable consequence of the ageing process for which there was little remedy.1 Bisphosphonates, fi rst synthesised in the 1800s but in clinical use only since the 1960s, demonstrated that this process of age-related decline in bone was, in fact, modifi able.2 M...